InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: KITLG

Summary

InnateDB Protein

IDBP-682200.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KITLG

Protein Name

Kit ligandSoluble KIT ligand

Synonyms

MGF;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000023349

InnateDB Gene

IDBG-630711 (KITLG)

Protein Structure

UniProt Annotation

Function

Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins (By similarity). {ECO:0000250}.

Subcellular Localization

Isoform 1: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.Isoform 2: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}.Soluble KIT ligand: Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005173	stem cell factor receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity

Biological Process

GO:0001755	neural crest cell migration
GO:0002763	positive regulation of myeloid leukocyte differentiation
GO:0007155	cell adhesion
GO:0008284	positive regulation of cell proliferation
GO:0008584	male gonad development
GO:0033026	negative regulation of mast cell apoptotic process
GO:0035162	embryonic hemopoiesis
GO:0035234	ectopic germ cell programmed cell death
GO:0043066	negative regulation of apoptotic process
GO:0043406	positive regulation of MAP kinase activity
GO:0045636	positive regulation of melanocyte differentiation
GO:0045740	positive regulation of DNA replication
GO:0046579	positive regulation of Ras protein signal transduction
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0070668	positive regulation of mast cell proliferation
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR003452 Stem cell factor
IPR009079 Four-helical cytokine-like, core

PFAM

PF02404

PRINTS

PIRSF

PIRSF015599

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q28132

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

281885

UniGene

Bt.354

RefSeq

NP_776800

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AB033716 AF120154 D28934

GenPept

AAD55355 BAA06061 BAA94808