Version 5.4
Bos taurus Gene: KITLG
Summary
InnateDB Gene IDBG-630711.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KITLG
Gene Name Kit ligand Soluble KIT ligand
Synonyms MGF
Species Bos taurus
Ensembl Gene ENSBTAG00000017549
Encoded Proteins
IDBP-682200
Kit ligandSoluble KIT ligand
IDBP-682202
Kit ligandSoluble KIT ligand
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 21262348
[Homo sapiens] KITLG is a PI3K-activating ligand that increases the secretion of IL6 and TNFA in LPS-stimulated mast cells, as well as the attenuating the production of IL1B. (Demonstrated in murine model)
PMID 21262348
[Mus musculus] Kitl is a PI3K-activating ligand that increases the secretion of Il6 and Tnfa in LPS-stimulated mast cells, as well as the attenuating the production of Il1b.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000049130:
This gene encodes the ligand of the tyrosine-kinase receptor encoded by the KIT locus. This ligand is a pleiotropic factor that acts in utero in germ cell and neural cell development, and hematopoiesis, all believed to reflect a role in cell migration. In adults, it functions pleiotropically, while mostly noted for its continued requirement in hematopoiesis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:18317748-18420025
Strand Reverse strand
Band
Transcripts
ENSBTAT00000023349 ENSBTAP00000023349
ENSBTAT00000065938 ENSBTAP00000055628
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005173 stem cell factor receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
Biological Process
GO:0001755 neural crest cell migration
GO:0002763 positive regulation of myeloid leukocyte differentiation
GO:0007155 cell adhesion
GO:0008284 positive regulation of cell proliferation
GO:0008584 male gonad development
GO:0033026 negative regulation of mast cell apoptotic process
GO:0035162 embryonic hemopoiesis
GO:0035234 ectopic germ cell programmed cell death
GO:0043066 negative regulation of apoptotic process
GO:0043406 positive regulation of MAP kinase activity
GO:0045636 positive regulation of melanocyte differentiation
GO:0045740 positive regulation of DNA replication
GO:0046579 positive regulation of Ras protein signal transduction
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0070668 positive regulation of mast cell proliferation
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000049130
View Gene Order
ENSMUSG00000019966
View Gene Order
Pathways
NETPATH
REACTOME
REACT_217956
DAP12 interactions pathway
REACT_208036
Signaling by EGFR pathway
REACT_222082
GAB1 signalosome pathway
REACT_204365
Signaling by PDGF pathway
REACT_216183
Signaling by ERBB4 pathway
REACT_202837
Signaling by FGFR pathway
REACT_215558
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_219416
PI3K events in ERBB2 signaling pathway
REACT_213138
Immune System pathway
REACT_215895
Constitutive PI3K/AKT Signaling in Cancer pathway
REACT_205435
Signaling by the B Cell Receptor (BCR) pathway
REACT_218958
Signaling by ERBB2 pathway
REACT_214353
Signal Transduction pathway
REACT_221368
Signaling by EGFR in Cancer pathway
REACT_204467
PI-3K cascade pathway
REACT_207949
NGF signalling via TRKA from the plasma membrane pathway
REACT_223238
Regulation of KIT signaling pathway
REACT_222492
PI3K events in ERBB4 signaling pathway
REACT_206613
Downstream signaling of activated FGFR pathway
REACT_207066
Signalling by NGF pathway
REACT_221870
PI3K/AKT Signaling in Cancer pathway
REACT_224097
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_214469
Adaptive Immune System pathway
REACT_212750
Downstream signal transduction pathway
REACT_208171
PIP3 activates AKT signaling pathway
REACT_204114
Signaling by SCF-KIT pathway
REACT_216714
Innate Immune System pathway
REACT_225332
PI3K/AKT activation pathway
REACT_214988
DAP12 signaling pathway
REACT_207087
Disease pathway
REACT_203736
Signaling by FGFR in disease pathway
REACT_225357
Fc epsilon receptor (FCERI) signaling pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_6
KitReceptor pathway
REACTOME
REACT_239142
Innate Immune System pathway
REACT_188199
Signaling by the B Cell Receptor (BCR) pathway
REACT_188191
Signaling by ERBB2 pathway
REACT_205300
PI3K/AKT activation pathway
REACT_189085
Disease pathway
REACT_227425
Regulation of KIT signaling pathway
REACT_188177
Signaling by FGFR in disease pathway
REACT_188579
Signaling by ERBB4 pathway
REACT_188578
Signaling by SCF-KIT pathway
REACT_226341
PIP3 activates AKT signaling pathway
REACT_230745
Immune System pathway
REACT_230639
Downstream signal transduction pathway
REACT_231729
Downstream signaling of activated FGFR pathway
REACT_196588
Constitutive PI3K/AKT Signaling in Cancer pathway
REACT_203296
PI3K events in ERBB4 signaling pathway
REACT_223993
PI-3K cascade pathway
REACT_242976
Signaling by EGFR pathway
REACT_213364
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_188204
Fc epsilon receptor (FCERI) signaling pathway
REACT_226735
PI3K/AKT Signaling in Cancer pathway
REACT_248921
Signalling by NGF pathway
REACT_229531
Adaptive Immune System pathway
REACT_263353
Signaling by PDGF pathway
REACT_206286
GAB1 signalosome pathway
REACT_237883
NGF signalling via TRKA from the plasma membrane pathway
REACT_215348
PI3K events in ERBB2 signaling pathway
REACT_188257
Signal Transduction pathway
REACT_242456
Signaling by FGFR pathway
REACT_188180
Signaling by EGFR in Cancer pathway
REACT_209507
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_188188
DAP12 interactions pathway
REACT_188185
DAP12 signaling pathway
KEGG
hsa04640
Hematopoietic cell lineage pathway
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04916
Melanogenesis pathway
hsa05200
Pathways in cancer pathway
mmu04060
Cytokine-cytokine receptor interaction pathway
mmu04640
Hematopoietic cell lineage pathway
mmu04916
Melanogenesis pathway
mmu05200
Pathways in cancer pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
INOH website
GPCR signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
GPCR signaling pathway
PID NCI
cmyb_pathway
C-MYB transcription factor network
kitpathway
Signaling events mediated by Stem cell factor receptor (c-Kit)
Cross-References
SwissProt
TrEMBL G5E6J2
UniProt Splice Variant
Entrez Gene 281885
UniGene Bt.354
RefSeq NM_174375
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02012658 DAAA02012659
GenPept
RNA Seq Atlas 281885

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca