InnateDB Protein
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IDBP-682319.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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UBE2N
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Protein Name
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Ubiquitin-conjugating enzyme E2 N
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Synonyms
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000052296
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InnateDB Gene
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IDBG-630838 (UBE2N)
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Protein Structure
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Function |
The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD (By similarity). Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes (By similarity). {ECO:0000250}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 121 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
121 [view]
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Molecular Function |
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Biological Process |
GO:0000724
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double-strand break repair via homologous recombination
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GO:0000729
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DNA double-strand break processing
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GO:0006281
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DNA repair
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GO:0006301
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postreplication repair
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GO:0006511
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ubiquitin-dependent protein catabolic process
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GO:0006974
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cellular response to DNA damage stimulus
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GO:0016567
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protein ubiquitination
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GO:0016574
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histone ubiquitination
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GO:0031058
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positive regulation of histone modification
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GO:0033182
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regulation of histone ubiquitination
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GO:0043123
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positive regulation of I-kappaB kinase/NF-kappaB signaling
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GO:0045739
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positive regulation of DNA repair
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GO:0050852
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T cell receptor signaling pathway
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GO:0051092
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positive regulation of NF-kappaB transcription factor activity
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GO:0051443
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positive regulation of ubiquitin-protein transferase activity
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GO:0070534
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protein K63-linked ubiquitination
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Cellular Component |
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PDB ID |
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InterPro |
IPR000608
Ubiquitin-conjugating enzyme, E2
IPR016135
Ubiquitin-conjugating enzyme/RWD-like
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PFAM |
PF00179
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q0P5K3
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
541130
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UniGene |
Bt.22061
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RefSeq |
NP_001069726
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HUGO |
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
BC119931
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GenPept |
AAI19932
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