Version 5.4
| Bos taurus Gene: UBE2N | |||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Summary | |||||||||||||||||||||||||||||||||
| InnateDB Gene | IDBG-630838.3 | ||||||||||||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||
| Gene Symbol | UBE2N | ||||||||||||||||||||||||||||||||
| Gene Name | Ubiquitin-conjugating enzyme E2 N | ||||||||||||||||||||||||||||||||
| Synonyms | |||||||||||||||||||||||||||||||||
| Species | Bos taurus | ||||||||||||||||||||||||||||||||
| Ensembl Gene | ENSBTAG00000021767 | ||||||||||||||||||||||||||||||||
| Encoded Proteins |
Ubiquitin-conjugating enzyme E2 N
|
||||||||||||||||||||||||||||||||
| Protein Structure |
|
||||||||||||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||
| InnateDB Annotation from Orthologs | |||||||||||||||||||||||||||||||||
| Summary |
[Homo sapiens] UBE2N abalation resulted in defective B cell development and in impaired B cell and macrophage activation.
[Homo sapiens] TRIM5 requires UBE2W, UBE2N and UBE2V2 enzymatic activities to inhibit retroviral DNA synthesis
|
||||||||||||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000177889:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Studies in mouse suggest that this protein plays a role in DNA postreplication repair. [provided by RefSeq, Jul 2008] |
||||||||||||||||||||||||||||||||
| Gene Information | |||||||||||||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||||||||||||
| Genomic Location | Chromosome 5:23370705-23411877 | ||||||||||||||||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||||||||||||||||
| Band | |||||||||||||||||||||||||||||||||
| Transcripts |
|
||||||||||||||||||||||||||||||||
| Interactions | |||||||||||||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 121 interaction(s) predicted by orthology.
|
||||||||||||||||||||||||||||||||
| Gene Ontology | |||||||||||||||||||||||||||||||||
Molecular Function |
|
||||||||||||||||||||||||||||||||
| Biological Process |
|
||||||||||||||||||||||||||||||||
| Cellular Component |
|
||||||||||||||||||||||||||||||||
| Orthologs | |||||||||||||||||||||||||||||||||
|
Species
Homo sapiens
Mus musculus
|
Gene ID
Gene Order
|
||||||||||||||||||||||||||||||||
| Pathways | |||||||||||||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||||||||||||
| REACTOME |
NOD1/2 Signaling Pathway pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
ISG15 antiviral mechanism pathway
Activated TLR4 signalling pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Cytokine Signaling in Immune system pathway
Downstream TCR signaling pathway
Immune System pathway
Antiviral mechanism by IFN-stimulated genes pathway
Toll-Like Receptors Cascades pathway
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
Interferon Signaling pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
FCERI mediated NF-kB activation pathway
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation pathway
Adaptive Immune System pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
MyD88 dependent cascade initiated on endosome pathway
Innate Immune System pathway
Interleukin-1 signaling pathway
Signaling by Interleukins pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Fc epsilon receptor (FCERI) signaling pathway
IRAK1 recruits IKK complex pathway
MyD88 cascade initiated on plasma membrane pathway
TCR signaling pathway
|
||||||||||||||||||||||||||||||||
| KEGG | |||||||||||||||||||||||||||||||||
| INOH | |||||||||||||||||||||||||||||||||
| PID NCI | |||||||||||||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||||||
| NETPATH |
IL1 pathway
|
||||||||||||||||||||||||||||||||
| REACTOME |
Antigen processing: Ubiquitination & Proteasome degradation pathway
IKK complex recruitment mediated by RIP1 pathway
MyD88-independent cascade pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
IRAK1 recruits IKK complex pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling pathway
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
MyD88 dependent cascade initiated on endosome pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
MyD88 cascade initiated on plasma membrane pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
NOD1/2 Signaling Pathway pathway
Downstream TCR signaling pathway
ISG15 antiviral mechanism pathway
Interleukin-1 signaling pathway
FCERI mediated NF-kB activation pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
TCR signaling pathway
Antiviral mechanism by IFN-stimulated genes pathway
Cytokine Signaling in Immune system pathway
Innate Immune System pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Toll-Like Receptors Cascades pathway
Fc epsilon receptor (FCERI) signaling pathway
Interferon Signaling pathway
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
Adaptive Immune System pathway
Immune System pathway
Signaling by Interleukins pathway
Activated TLR4 signalling pathway
Class I MHC mediated antigen processing & presentation pathway
TRIF-mediated TLR3/TLR4 signaling pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Innate Immune System pathway
Downstream TCR signaling pathway
MyD88 cascade initiated on plasma membrane pathway
FCERI mediated NF-kB activation pathway
Cytokine Signaling in Immune system pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Antiviral mechanism by IFN-stimulated genes pathway
ISG15 antiviral mechanism pathway
Immune System pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
Interferon Signaling pathway
Fc epsilon receptor (FCERI) signaling pathway
Toll-Like Receptors Cascades pathway
Signaling by Interleukins pathway
NOD1/2 Signaling Pathway pathway
MyD88 dependent cascade initiated on endosome pathway
Adaptive Immune System pathway
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
Activated TLR4 signalling pathway
Interleukin-1 signaling pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
TCR signaling pathway
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation pathway
IRAK1 recruits IKK complex pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
|
||||||||||||||||||||||||||||||||
| KEGG |
Ubiquitin mediated proteolysis pathway
Ubiquitin mediated proteolysis pathway
|
||||||||||||||||||||||||||||||||
| INOH |
CD4 T cell receptor signaling pathway
IL-1 signaling pathway pathway
Toll-like receptor signaling pathway pathway
B cell receptor signaling pathway
CD4 T cell receptor signaling pathway
IL-1 signaling pathway pathway
Toll-like receptor signaling pathway pathway
B cell receptor signaling pathway
|
||||||||||||||||||||||||||||||||
| PID NCI |
IL1-mediated signaling events
ATM pathway
|
||||||||||||||||||||||||||||||||
| Cross-References | |||||||||||||||||||||||||||||||||
| SwissProt | Q0P5K3 | ||||||||||||||||||||||||||||||||
| TrEMBL | |||||||||||||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||||||||||||
| Entrez Gene | 541130 | ||||||||||||||||||||||||||||||||
| UniGene | Bt.102001 Bt.22061 | ||||||||||||||||||||||||||||||||
| RefSeq | NM_001076258 | ||||||||||||||||||||||||||||||||
| HUGO | |||||||||||||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||||||||||||
| CCDS | |||||||||||||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||||||||||||
| EMBL | BC119931 | ||||||||||||||||||||||||||||||||
| GenPept | AAI19932 | ||||||||||||||||||||||||||||||||
| RNA Seq Atlas | 541130 | ||||||||||||||||||||||||||||||||