InnateDB Protein
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IDBP-682533.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PYCR2
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Protein Name
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Pyrroline-5-carboxylate reductase 2
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Synonyms
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000000047
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InnateDB Gene
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IDBG-631039 (PYCR2)
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Protein Structure
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Function |
Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+). Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
10 [view]
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Molecular Function |
Accession |
GO Term |
GO:0004735
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pyrroline-5-carboxylate reductase activity
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GO:0016491
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oxidoreductase activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000304
Pyrroline-5-carboxylate reductase
IPR008927
6-phosphogluconate dehydrogenase, C-terminal-like
IPR028939
Pyrroline-5-carboxylate reductase, catalytic, N-terminal
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PFAM |
PF03807
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PRINTS |
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PIRSF |
PIRSF000193
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q17QJ7
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
504987
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UniGene |
Bt.7679
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RefSeq |
NP_001068649
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HUGO |
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
BC118324
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GenPept |
AAI18325
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