Version 5.4
Bos taurus Protein: CD40LG
Summary
InnateDB Protein IDBP-682796.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD40LG
Protein Name CD40 ligandCD40 ligand, membrane formCD40 ligand, soluble form
Synonyms TNFSF5;
Species Bos taurus
Ensembl Protein ENSBTAP00000023717
InnateDB Gene IDBG-631246 (CD40LG)
Protein Structure
UniProt Annotation
Function Cytokine that binds to TNFRSF5. Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching (By similarity). {ECO:0000250}.Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and an matrix metalloproteinases (MMP) inhibitor-sensitive pathway. {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.CD40 ligand, soluble form: Secreted {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005164 tumor necrosis factor receptor binding
GO:0005174 CD40 receptor binding
GO:0005515 protein binding
Biological Process
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0030168 platelet activation
GO:0042100 B cell proliferation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR003263 Tumour necrosis factor ligand 5
IPR006052 Tumour necrosis factor domain
IPR008983 Tumour necrosis factor-like domain
PFAM PF00229
PRINTS PR01702
PIRSF PIRSF016527
SMART SM00207
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P51749
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 282387
UniGene Bt.49
RefSeq NP_777049
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL Z48469
GenPept CAA88363

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca