InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: ARHGEF6

Summary

InnateDB Protein

IDBP-682817.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARHGEF6

Protein Name

Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000023731

InnateDB Gene

IDBG-631282 (ARHGEF6)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding

Biological Process

GO:0030032	lamellipodium assembly
GO:0032321	positive regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0035556	intracellular signal transduction
GO:0043547	positive regulation of GTPase activity

Cellular Component

GO:0005911	cell-cell junction
GO:0030027	lamellipodium

Protein Structure and Domains

PDB ID

InterPro

IPR000219 Dbl homology (DH) domain
IPR001452 SH3 domain
IPR001715 Calponin homology domain
IPR001849 Pleckstrin homology domain
IPR011511 Variant SH3 domain
IPR022613 Calmodulin-regulated spectrin-associated protein, CH domain

PFAM