InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: ADSS

Summary

InnateDB Protein

IDBP-682886.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADSS

Protein Name

Adenylosuccinate synthetase isozyme 2

Synonyms

ADSS2; AMPASE2;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000044296

InnateDB Gene

IDBG-631352 (ADSS)

Protein Structure

UniProt Annotation

Function

Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000255HAMAP-Rule:MF_03127}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0000287	magnesium ion binding
GO:0004019	adenylosuccinate synthase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0006164	purine nucleotide biosynthetic process
GO:0006167	AMP biosynthetic process
GO:0044208	'de novo' AMP biosynthetic process

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001114 Adenylosuccinate synthetase
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00709

PRINTS

PIRSF

SMART

SM00788

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A7MBG0

PhosphoSite

PhosphoSite-

TrEMBL

Q6PWM0

UniProt Splice Variant

Entrez Gene

522529

UniGene

Bt.69452

RefSeq

NP_001161281

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AY573611 BC151541

GenPept

AAI51542 AAS86203