Bos taurus Protein: BT.22873
Summary
InnateDB Protein IDBP-682955.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.22873
Protein Name Tyrosine-protein kinase receptor
Synonyms TRKA;
Species Bos taurus
Ensembl Protein ENSBTAP00000003980
InnateDB Gene IDBG-631386 (BT.22873)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.
Predicted by orthology
Total 42 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005030 neurotrophin receptor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0010465 nerve growth factor receptor activity
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0042803 protein homodimerization activity
GO:0048406 nerve growth factor binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007399 nervous system development
GO:0007623 circadian rhythm
GO:0008285 negative regulation of cell proliferation
GO:0010976 positive regulation of neuron projection development
GO:0016310 phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030183 B cell differentiation
GO:0032320 positive regulation of Ras GTPase activity
GO:0042490 mechanoreceptor differentiation
GO:0043524 negative regulation of neuron apoptotic process
GO:0045766 positive regulation of angiogenesis
GO:0046579 positive regulation of Ras protein signal transduction
GO:0046777 protein autophosphorylation
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048485 sympathetic nervous system development
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0060385 axonogenesis involved in innervation
GO:0070374 positive regulation of ERK1 and ERK2 cascade
Cellular Component
GO:0005737 cytoplasm
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043235 receptor complex
Protein Structure and Domains
PDB ID
InterPro IPR000483 Cysteine-rich flanking region, C-terminal
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR007110 Immunoglobulin-like domain
IPR011009 Protein kinase-like domain
IPR020461 Tyrosine-protein kinase, neurotrophic receptor, type 1
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR020777 Tyrosine-protein kinase, neurotrophic receptor
PFAM PF01463
PF00069
PF07714
PRINTS PR00109
PR01940
PR01939
PIRSF
SMART SM00082
SM00220
SM00219
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL F1MC14
UniProt Splice Variant
Entrez Gene 353111
UniGene
RefSeq XP_002686011
HUGO HGNC:8031
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02007120
GenPept