InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: RELN

Summary

InnateDB Protein

IDBP-683327.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RELN

Protein Name

Reelin

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000004768

InnateDB Gene

IDBG-631504 (RELN)

Protein Structure

UniProt Annotation

Function

Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000250}.

Disease Associations

Tissue Specificity

Abundantly produced during brain ontogenesis by the Cajal-Retzius cells and other pioneer neurons located in the telencephalic marginal zone and by granule cells of the external granular layer of the cerebellum.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008236	serine-type peptidase activity
GO:0016787	hydrolase activity
GO:0046872	metal ion binding

Biological Process

GO:0006508	proteolysis
GO:0007155	cell adhesion
GO:0007275	multicellular organismal development

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix

Protein Structure and Domains

PDB ID

InterPro

IPR000742 Epidermal growth factor-like domain
IPR002860 BNR repeat
IPR009030 Insulin-like growth factor binding protein, N-terminal
IPR011040 Sialidases
IPR013111 EGF-like domain, extracellular

PFAM

PF00008
PF02012
PF07974

PRINTS

PIRSF

SMART

SM00181

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9N117