InnateDB Protein
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IDBP-683360.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RELN
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Protein Name
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Reelin
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Synonyms
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000055787
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InnateDB Gene
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IDBG-631504 (RELN)
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Protein Structure
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Function |
Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation (By similarity). {ECO:0000250}.
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Subcellular Localization |
Secreted, extracellular space, extracellular matrix {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Abundantly produced during brain ontogenesis by the Cajal-Retzius cells and other pioneer neurons located in the telencephalic marginal zone and by granule cells of the external granular layer of the cerebellum.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
6 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002861
Reeler domain
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PFAM |
PF02014
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9N117
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PhosphoSite |
PhosphoSite-
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TrEMBL |
A5PKC5
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UniProt Splice Variant |
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Entrez Gene |
281450
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UniGene |
Bt.82217
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RefSeq |
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HUGO |
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AF232904
BC142438
DAAA02010510
DAAA02010511
DAAA02010512
DAAA02010513
DAAA02010514
DAAA02010515
DAAA02010516
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GenPept |
AAF64286
AAI42439
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