InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: XDH

Summary

InnateDB Protein

IDBP-683494.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

XDH

Protein Name

xanthine dehydrogenase/oxidase

Synonyms

XOR;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000016620

InnateDB Gene

IDBG-631874 (XDH)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004854	xanthine dehydrogenase activity
GO:0004855	xanthine oxidase activity
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0008762	UDP-N-acetylmuramate dehydrogenase activity
GO:0009055	electron carrier activity
GO:0016491	oxidoreductase activity
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors
GO:0042803	protein homodimerization activity
GO:0043546	molybdopterin cofactor binding
GO:0046872	metal ion binding
GO:0050660	flavin adenine dinucleotide binding
GO:0051536	iron-sulfur cluster binding
GO:0051537	2 iron, 2 sulfur cluster binding

Biological Process

GO:0001933	negative regulation of protein phosphorylation
GO:0001937	negative regulation of endothelial cell proliferation
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007595	lactation
GO:0009115	xanthine catabolic process
GO:0010629	negative regulation of gene expression
GO:0030856	regulation of epithelial cell differentiation
GO:0045602	negative regulation of endothelial cell differentiation
GO:0051898	negative regulation of protein kinase B signaling
GO:0055114	oxidation-reduction process
GO:1900745	positive regulation of p38MAPK cascade
GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway
GO:2000379	positive regulation of reactive oxygen species metabolic process
GO:2001213	negative regulation of vasculogenesis

Cellular Component

GO:0005615

extracellular space

Protein Structure and Domains

PDB ID

InterPro

IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead
IPR001041 2Fe-2S ferredoxin-type domain
IPR002346 Molybdopterin dehydrogenase, FAD-binding
IPR002888 [2Fe-2S]-binding
IPR005107 CO dehydrogenase flavoprotein, C-terminal
IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding
IPR014307 Xanthine dehydrogenase, small subunit
IPR016166 FAD-binding, type 2
IPR016208 Aldehyde oxidase/xanthine dehydrogenase

PFAM

PF01315
PF00111
PF00941
PF01799
PF03450
PF02738

PRINTS

PIRSF

PIRSF000127

SMART

SM01008
SM01092

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt