InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: GRIK2

Summary

InnateDB Protein

IDBP-683555.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GRIK2

Protein Name

glutamate receptor, ionotropic, kainate 2

Synonyms

GRIK5;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000015563

InnateDB Gene

IDBG-631973 (GRIK2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0004970	ionotropic glutamate receptor activity
GO:0005215	transporter activity
GO:0005216	ion channel activity
GO:0005234	extracellular-glutamate-gated ion channel activity
GO:0005515	protein binding
GO:0015277	kainate selective glutamate receptor activity

Biological Process

GO:0001662	behavioral fear response
GO:0006810	transport
GO:0006811	ion transport
GO:0006874	cellular calcium ion homeostasis
GO:0006886	intracellular protein transport
GO:0007268	synaptic transmission
GO:0019228	neuronal action potential
GO:0034220	ion transmembrane transport
GO:0035235	ionotropic glutamate receptor signaling pathway
GO:0035249	synaptic transmission, glutamatergic
GO:0042391	regulation of membrane potential
GO:0043524	negative regulation of neuron apoptotic process
GO:0048169	regulation of long-term neuronal synaptic plasticity
GO:0048172	regulation of short-term neuronal synaptic plasticity
GO:0050804	regulation of synaptic transmission
GO:0050806	positive regulation of synaptic transmission
GO:0051967	negative regulation of synaptic transmission, glutamatergic
GO:0060079	regulation of excitatory postsynaptic membrane potential
GO:0060080	regulation of inhibitory postsynaptic membrane potential

Cellular Component

GO:0005886	plasma membrane
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030425	dendrite
GO:0032983	kainate selective glutamate receptor complex
GO:0042734	presynaptic membrane
GO:0043025	neuronal cell body
GO:0045202	synapse
GO:0045211	postsynaptic membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001320 Ionotropic glutamate receptor
IPR001508 NMDA receptor
IPR001638 Extracellular solute-binding protein, family 3
IPR001828 Extracellular ligand-binding receptor
IPR019594 Glutamate receptor, L-glutamate/glycine-binding
IPR028082 Periplasmic binding protein-like I

PFAM

PF00060
PF00497
PF01094
PF10613

PRINTS

PR00177

PIRSF

SMART

SM00079
SM00062
SM00918

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt