InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: EDNRB

Summary

InnateDB Protein

IDBP-683580.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EDNRB

Protein Name

Endothelin B receptor

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000006979

InnateDB Gene

IDBG-631994 (EDNRB)

Protein Structure

UniProt Annotation

Function

Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0004930	G-protein coupled receptor activity
GO:0004962	endothelin receptor activity
GO:0005515	protein binding
GO:0017046	peptide hormone binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001755	neural crest cell migration
GO:0006885	regulation of pH
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007422	peripheral nervous system development
GO:0007497	posterior midgut development
GO:0008217	regulation of blood pressure
GO:0014043	negative regulation of neuron maturation
GO:0014826	vein smooth muscle contraction
GO:0030318	melanocyte differentiation
GO:0032269	negative regulation of cellular protein metabolic process
GO:0035645	enteric smooth muscle cell differentiation
GO:0042310	vasoconstriction
GO:0043473	pigmentation
GO:0048066	developmental pigmentation
GO:0048246	macrophage chemotaxis
GO:0048484	enteric nervous system development

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000499 Endothelin receptor family
IPR001112 Endothelin receptor B
IPR001556 Bombesin receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR00366
PR00571
PR00358

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P28088