Version 5.4
| Bos taurus Protein: MPP1 | |||||||||||
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| Summary | |||||||||||
| InnateDB Protein | IDBP-683732.2 | ||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
| Gene Symbol | MPP1 | ||||||||||
| Protein Name | 55 kDa erythrocyte membrane protein | ||||||||||
| Synonyms | |||||||||||
| Species | Bos taurus | ||||||||||
| Ensembl Protein | ENSBTAP00000017340 | ||||||||||
| InnateDB Gene | IDBG-632136 (MPP1) | ||||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||||
| Function | Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity (By similarity). {ECO:0000250}. | ||||||||||
| Subcellular Localization | Membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Cell projection, stereocilium {ECO:0000250}. Note=Colocalizes with WHRN at stereocilium tip during hair cell development. Colocalizes with MPP5 in the retina, at the outer limiting membrane (OLM). Colocalizes with WHRN in the retina, at the outer limiting membrane (OLM), outer plexifirm layer (OPL), basal bodies and at the connecting cilium (CC). Colocalizes with NF2 in non-myelin-forming Schwann cells (By similarity). {ECO:0000250}. | ||||||||||
| Disease Associations | |||||||||||
| Tissue Specificity | |||||||||||
| Comments | |||||||||||
| Interactions | |||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||||
| PDB ID | |||||||||||
| InterPro |
IPR001452
SH3 domain IPR001478 PDZ domain IPR008144 Guanylate kinase-like IPR008145 Guanylate kinase/L-type calcium channel beta subunit IPR011511 Variant SH3 domain IPR027417 P-loop containing nucleoside triphosphate hydrolase |
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| PFAM |
PF00018
PF14604 PF00595 PF13180 PF00625 PF07653 |
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| PRINTS |
PR00452
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| PIRSF | |||||||||||
| SMART |
SM00326
SM00228 SM00072 |
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| TIGRFAMs | |||||||||||
| Post-translational Modifications | |||||||||||
| Modification | |||||||||||
| Cross-References | |||||||||||
| SwissProt | Q17QN6 | ||||||||||
| PhosphoSite | PhosphoSite- | ||||||||||
| TrEMBL | |||||||||||
| UniProt Splice Variant | |||||||||||
| Entrez Gene | 510998 | ||||||||||
| UniGene | Bt.12870 | ||||||||||
| RefSeq | NP_001068952 | ||||||||||
| HUGO | |||||||||||
| OMIM | |||||||||||
| CCDS | |||||||||||
| HPRD | |||||||||||
| IMGT | |||||||||||
| EMBL | BC118256 | ||||||||||
| GenPept | AAI18257 | ||||||||||