InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: FLOT2

Summary

InnateDB Protein

IDBP-683748.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FLOT2

Protein Name

Flotillin-2

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000013288

InnateDB Gene

IDBG-632132 (FLOT2)

Protein Structure

UniProt Annotation

Function

May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Membrane, caveola {ECO:0000250}; Peripheral membrane protein. Endosome {ECO:0000250}. Note=Membrane-associated protein of caveolae. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.

Predicted by orthology
Total	34 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007155	cell adhesion
GO:0010629	negative regulation of gene expression
GO:0050821	protein stabilization
GO:0090002	establishment of protein localization to plasma membrane
GO:1902992	negative regulation of amyloid precursor protein catabolic process

Cellular Component

GO:0002080	acrosomal membrane
GO:0005768	endosome
GO:0005886	plasma membrane
GO:0005901	caveola
GO:0016020	membrane
GO:0016600	flotillin complex
GO:0030139	endocytic vesicle
GO:0031982	vesicle
GO:0045121	membrane raft
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome