InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KDM4D

Summary

InnateDB Protein

IDBP-68446.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KDM4D

Protein Name

lysine (K)-specific demethylase 4D

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000334181

InnateDB Gene

IDBG-68444 (KDM4D)

Protein Structure

UniProt Annotation

Function

Histone demethylase that specifically demethylates 'Lys- 9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys- 9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. {ECO:0000269PubMed:16603238}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00537}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0046872	metal ion binding
GO:0051213	dioxygenase activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0033169	histone H3-K9 demethylation
GO:0055114	oxidation-reduction process