InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: MET

Summary

InnateDB Protein

IDBP-684485.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MET

Protein Name

hepatocyte growth factor receptor precursor

Synonyms

c-met; HGFR;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000008102

InnateDB Gene

IDBG-632820 (MET)

Protein Structure

UniProt Annotation

Function

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000269PubMed:16207523}; Single-pass type I membrane protein {ECO:0000269PubMed:16207523}.

Disease Associations

Tissue Specificity

Expressed in many tissues, including liver, lung, heart, spleen and mammary gland. {ECO:0000269PubMed:16207523}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 53 interaction(s) predicted by orthology.

Predicted by orthology
Total	53 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004714	transmembrane receptor protein tyrosine kinase activity
GO:0004872	receptor activity
GO:0005008	hepatocyte growth factor-activated receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019903	protein phosphatase binding

Biological Process

GO:0000187	activation of MAPK activity
GO:0001889	liver development
GO:0001890	placenta development
GO:0006468	protein phosphorylation
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275	multicellular organismal development
GO:0007420	brain development
GO:0007517	muscle organ development
GO:0007519	skeletal muscle tissue development
GO:0010828	positive regulation of glucose transport
GO:0014812	muscle cell migration
GO:0014902	myotube differentiation
GO:0016310	phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030534	adult behavior
GO:0042593	glucose homeostasis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046777	protein autophosphorylation
GO:0048012	hepatocyte growth factor receptor signaling pathway
GO:0048754	branching morphogenesis of an epithelial tube
GO:0050918	positive chemotaxis
GO:0051450	myoblast proliferation
GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
GO:0071526	semaphorin-plexin signaling pathway
GO:1901299	negative regulation of hydrogen peroxide-mediated programmed cell death
GO:2001028	positive regulation of endothelial cell chemotaxis

Cellular Component

GO:0009925	basal plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001627 Sema domain
IPR002165 Plexin
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR002909 IPT domain
IPR011009 Protein kinase-like domain
IPR014756 Immunoglobulin E-set
IPR016201 Plexin-like fold
IPR016244 Tyrosine-protein kinase, HGF/MSP receptor
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF01403
PF01437
PF01833

PRINTS

PR00109

PIRSF

PIRSF000617

SMART

SM00630
SM00220
SM00429
SM00423
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References