InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: BT.49331

Summary

InnateDB Protein

IDBP-684519.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.49331

Protein Name

transitional endoplasmic reticulum ATPase

Synonyms

p97;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000019970

InnateDB Gene

IDBG-632847 (BT.49331)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 442 interaction(s) predicted by orthology.

Predicted by orthology
Total	442 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0009378	four-way junction helicase activity
GO:0016787	hydrolase activity
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0019903	protein phosphatase binding
GO:0019904	protein domain specific binding
GO:0031593	polyubiquitin binding
GO:0035800	deubiquitinase activator activity
GO:0044822	poly(A) RNA binding
GO:1990381	ubiquitin-specific protease binding

Biological Process

GO:0006281	DNA repair
GO:0006302	double-strand break repair
GO:0006310	DNA recombination
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006974	cellular response to DNA damage stimulus
GO:0018279	protein N-linked glycosylation via asparagine
GO:0019985	translesion synthesis
GO:0030970	retrograde protein transport, ER to cytosol
GO:0031334	positive regulation of protein complex assembly
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0045732	positive regulation of protein catabolic process
GO:0070842	aggresome assembly
GO:1903006	positive regulation of protein K63-linked deubiquitination
GO:1903007	positive regulation of Lys63-specific deubiquitinase activity

Cellular Component

GO:0000502	proteasome complex
GO:0000836	Hrd1p ubiquitin ligase complex
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005811	lipid particle
GO:0005829	cytosol
GO:0035861	site of double-strand break
GO:0043234	protein complex
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR003338 CDC48, N-terminal subdomain
IPR003593 AAA+ ATPase domain
IPR003959 ATPase, AAA-type, core
IPR004201 CDC48, domain 2
IPR005938 AAA ATPase, CDC48 family
IPR008824 DNA helicase, Holliday junction RuvB type, N-terminal
IPR009010 Aspartate decarboxylase-like domain
IPR011704 ATPase, dynein-related, AAA domain
IPR015415 Vps4 oligomerisation, C-terminal
IPR027417 P-loop containing nucleoside triphosphate hydrolase
IPR029067 CDC48 domain 2-like

PFAM