InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: RNF34

Summary

InnateDB Protein

IDBP-684673.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RNF34

Protein Name

E3 ubiquitin-protein ligase RNF34

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000002986

InnateDB Gene

IDBG-633010 (RNF34)

Protein Structure

UniProt Annotation

Function

Has E3 ubiquitin-protein ligase activity. Regulates the levels of CASP8 and CASP10 by targeting them for proteasomal degradation. Protects cells against apoptosis induced by TNF. Binds phosphatidylinositol 5-phosphate and phosphatidylinositol 3- phosphate (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus speckle {ECO:0000250}. Endomembrane system {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding
GO:1901981	phosphatidylinositol phosphate binding

Biological Process

GO:0006915	apoptotic process
GO:0016567	protein ubiquitination
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2001271	negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis