Version 5.4
Bos taurus Protein: HCLS1
Summary
InnateDB Protein IDBP-684719.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HCLS1
Protein Name hematopoietic lineage cell-specific protein
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000001338
InnateDB Gene IDBG-633047 (HCLS1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.
Predicted by orthology
Total 27 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001085 RNA polymerase II transcription factor binding
GO:0003779 actin binding
GO:0005515 protein binding
GO:0017124 SH3 domain binding
GO:0019901 protein kinase binding
GO:0032403 protein complex binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0008284 positive regulation of cell proliferation
GO:0009725 response to hormone
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0030041 actin filament polymerization
GO:0030218 erythrocyte differentiation
GO:0030833 regulation of actin filament polymerization
GO:0030854 positive regulation of granulocyte differentiation
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042993 positive regulation of transcription factor import into nucleus
GO:0045651 positive regulation of macrophage differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0051897 positive regulation of protein kinase B signaling
GO:0071345 cellular response to cytokine stimulus
GO:2000107 negative regulation of leukocyte apoptotic process
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR001452 SH3 domain
IPR003134 Hs1/Cortactin
IPR011511 Variant SH3 domain
PFAM PF00018
PF14604
PF02218
PF07653
PRINTS PR00452
PIRSF
SMART SM00326
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q3SYW3
UniProt Splice Variant
Entrez Gene 508445
UniGene Bt.8820
RefSeq NP_001030229
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC103355 DAAA02001584
GenPept AAI03356

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca