InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: VPS29

Summary

InnateDB Protein

IDBP-684820.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VPS29

Protein Name

Vacuolar protein sorting-associated protein 29

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000011076

InnateDB Gene

IDBG-633135 (VPS29)

Protein Structure

UniProt Annotation

Function

Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Has low protein phosphatase activity towards a serine-phosphorylated peptide derived from IGF2R (in vitro) (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004647	phosphoserine phosphatase activity
GO:0016787	hydrolase activity
GO:0046872	metal ion binding

Biological Process

GO:0006810	transport
GO:0008152	metabolic process
GO:0015031	protein transport
GO:0016311	dephosphorylation
GO:0042147	retrograde transport, endosome to Golgi

Cellular Component

GO:0005737	cytoplasm
GO:0005768	endosome
GO:0010008	endosome membrane
GO:0016020	membrane
GO:0030904	retromer complex
GO:0043231	intracellular membrane-bounded organelle