InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: TRADD

Summary

InnateDB Protein

IDBP-684998.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRADD

Protein Name

Tumor necrosis factor receptor type 1-associated DEATH domain protein

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000016776

InnateDB Gene

IDBG-633302 (TRADD)

Protein Structure

UniProt Annotation

Function

Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B (By similarity). The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Shuttles between the cytoplasm and the nucleus. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 77 interaction(s) predicted by orthology.

Predicted by orthology
Total	77 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0019900	kinase binding
GO:0042802	identical protein binding
GO:0060090	binding, bridging
GO:0070513	death domain binding

Biological Process

GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0051798	positive regulation of hair follicle development
GO:0097191	extrinsic apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0043235	receptor complex

Protein Structure and Domains

PDB ID

InterPro

IPR000488 Death domain
IPR009095 TRADD, N-terminal
IPR011029 Death-like domain

PFAM

PF00531
PF09034

PRINTS

PIRSF

SMART

SM00005

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q2KI74

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

504707

UniGene

Bt.15875

RefSeq

NP_001039361

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC112743

GenPept

AAI12744