InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: ATP6V0D1

Summary

InnateDB Protein

IDBP-685278.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP6V0D1

Protein Name

V-type proton ATPase subunit d 1

Synonyms

ATP6D; ATP6DV;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000019346

InnateDB Gene

IDBG-633557 (ATP6V0D1)

Protein Structure

UniProt Annotation

Function

Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Localizes to centrosome and the base of the cilium. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism
GO:0015078	hydrogen ion transmembrane transporter activity

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0015991	ATP hydrolysis coupled proton transport
GO:0015992	proton transport
GO:0030030	cell projection organization
GO:0042384	cilium assembly

Cellular Component

GO:0005765	lysosomal membrane
GO:0005769	early endosome
GO:0005813	centrosome
GO:0016020	membrane
GO:0033179	proton-transporting V-type ATPase, V0 domain
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR002843 ATPase, V0 complex, c/d subunit
IPR016727 ATPase, V0 complex, subunit d

PFAM

PF01992

PRINTS

PIRSF

PIRSF018497

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P61420

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

282148

UniGene

Bt.1575

RefSeq

NP_776930

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC102305 J04204

GenPept

AAA64520 AAI02306