InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: BT.76143

Summary

InnateDB Protein

IDBP-685607.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.76143

Protein Name

STIP1 homology and U box-containing protein 1

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000025473

InnateDB Gene

IDBG-633868 (BT.76143)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 154 interaction(s) predicted by orthology.

Predicted by orthology
Total	154 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0019900	kinase binding
GO:0030544	Hsp70 protein binding
GO:0030911	TPR domain binding
GO:0031625	ubiquitin protein ligase binding
GO:0034450	ubiquitin-ubiquitin ligase activity
GO:0042803	protein homodimerization activity
GO:0046332	SMAD binding
GO:0051787	misfolded protein binding
GO:0051879	Hsp90 protein binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0006515	misfolded or incompletely synthesized protein catabolic process
GO:0016567	protein ubiquitination
GO:0030579	ubiquitin-dependent SMAD protein catabolic process
GO:0031398	positive regulation of protein ubiquitination
GO:0031943	regulation of glucocorticoid metabolic process
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865	protein autoubiquitination
GO:0070534	protein K63-linked ubiquitination
GO:0071218	cellular response to misfolded protein
GO:0090035	positive regulation of chaperone-mediated protein complex assembly

Cellular Component

GO:0000151	ubiquitin ligase complex
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0042405	nuclear inclusion body
GO:0045111	intermediate filament cytoskeleton
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001440 Tetratricopeptide TPR1
IPR003613 U box domain
IPR013026 Tetratricopeptide repeat-containing domain
IPR013105 Tetratricopeptide TPR2
IPR019734 Tetratricopeptide repeat

PFAM

PF00515
PF04564
PF07719
PF13174
PF13176
PF13181

PRINTS

PIRSF

SMART

SM00504
SM00028

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite