InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SENP2

Summary

InnateDB Protein

IDBP-68572.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SENP2

Protein Name

SUMO1/sentrin/SMT3 specific peptidase 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000296257

InnateDB Gene

IDBG-68570 (SENP2)

Protein Structure

UniProt Annotation

Function

Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway. Deconjugates SUMO2 from MTA1. {ECO:0000269PubMed:11896061, ECO:0000269PubMed:12192048, ECO:0000269PubMed:21965678}.

Subcellular Localization

Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Cytoplasm. Note=Shuttles between cytoplasm and nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008234	cysteine-type peptidase activity
GO:0016929	SUMO-specific protease activity
GO:0019904	protein domain specific binding

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0006508	proteolysis
GO:0007507	heart development
GO:0009950	dorsal/ventral axis specification
GO:0015031	protein transport
GO:0016055	Wnt signaling pathway
GO:0016925	protein sumoylation
GO:0016926	protein desumoylation
GO:0030111	regulation of Wnt signaling pathway
GO:0032091	negative regulation of protein binding
GO:0032875	regulation of DNA endoreduplication
GO:0035562	negative regulation of chromatin binding
GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051028	mRNA transport
GO:0051246	regulation of protein metabolic process
GO:0060707	trophoblast giant cell differentiation
GO:0060711	labyrinthine layer development
GO:0060712	spongiotrophoblast layer development
GO:1901797	negative regulation of signal transduction by p53 class mediator
GO:2000045	regulation of G1/S transition of mitotic cell cycle

Cellular Component

GO:0005634	nucleus
GO:0005643	nuclear pore
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0016604	nuclear body
GO:0016605	PML body
GO:0031410	cytoplasmic vesicle
GO:0031965	nuclear membrane