Version 5.4
Homo sapiens Gene: SENP2
Summary
InnateDB Gene IDBG-68570.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SENP2
Gene Name SUMO1/sentrin/SMT3 specific peptidase 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000163904
Encoded Proteins
IDBP-68572
SUMO1/sentrin/SMT3 specific peptidase 2
IDBP-386276
SUMO1/sentrin/SMT3 specific peptidase 2
IDBP-386285
SUMO1/sentrin/SMT3 specific peptidase 2
IDBP-386288
SUMO1/sentrin/SMT3 specific peptidase 2
IDBP-386289
SUMO1/sentrin/SMT3 specific peptidase 2
IDBP-386290
SUMO1/sentrin/SMT3 specific peptidase 2
IDBP-386291
SUMO1/sentrin/SMT3 specific peptidase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22028379
SENP2 acts as a negative regulator of virus-triggered IFN-beta induction by deSUMOylating IRF3 and conditioning it for ubiquitination and degradation. (Demonstrated in mice)
InnateDB Annotation from Orthologs
Summary
PMID 22028379
[Mus musculus] Senp2 acts as a negative regulator of virus-triggered IFN-beta induction by deSUMOylating Irf3 and conditioning it for ubiquitination and degradation.
Entrez Gene
Summary SUMO1 (UBL1; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species.[supplied by OMIM, Apr 2004]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:185582496-185633551
Strand Forward strand
Band q27.2
Transcripts
ENST00000296257 ENSP00000296257
ENST00000430355 ENSP00000399156
ENST00000453532 ENSP00000393197
ENST00000413407 ENSP00000388893
ENST00000439684 ENSP00000390229
ENST00000458551 ENSP00000408114
ENST00000444509 ENSP00000399201
ENST00000465201
ENST00000473760
ENST00000459883
ENST00000478001
ENST00000476011
ENST00000483005
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 22 [view]
Protein-Protein 21 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008234 cysteine-type peptidase activity
GO:0016929 SUMO-specific protease activity
GO:0019904 protein domain specific binding
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0006508 proteolysis
GO:0007507 heart development
GO:0009950 dorsal/ventral axis specification
GO:0015031 protein transport
GO:0016055 Wnt signaling pathway
GO:0016925 protein sumoylation
GO:0016926 protein desumoylation
GO:0030111 regulation of Wnt signaling pathway
GO:0032091 negative regulation of protein binding
GO:0032875 regulation of DNA endoreduplication
GO:0035562 negative regulation of chromatin binding
GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0045087 innate immune response (InnateDB)
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051028 mRNA transport
GO:0051246 regulation of protein metabolic process
GO:0060707 trophoblast giant cell differentiation
GO:0060711 labyrinthine layer development
GO:0060712 spongiotrophoblast layer development
GO:1901797 negative regulation of signal transduction by p53 class mediator
GO:2000045 regulation of G1/S transition of mitotic cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005643 nuclear pore
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0016604 nuclear body
GO:0016605 PML body
GO:0031410 cytoplasmic vesicle
GO:0031965 nuclear membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022855
View Gene Order
ENSBTAG00000001749
Not yet available
Pathways
NETPATH
REACTOME
REACT_22161
Post-translational protein modification pathway
REACT_163793
Processing and activation of SUMO pathway
REACT_17015
Metabolism of proteins pathway
REACT_163725
SUMO is proteolytically processed pathway
REACT_163823
SUMOylation pathway
KEGG
hsa04310
Wnt signaling pathway pathway
hsa03013
RNA transport pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.401388 Hs.707383
RefSeq NM_021627
HUGO
OMIM
CCDS CCDS33902
HPRD 07002
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca