Homo sapiens Protein: IGF2BP2 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Protein | IDBP-68596.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | IGF2BP2 | ||||||||||||||||||
Protein Name | insulin-like growth factor 2 mRNA binding protein 2 | ||||||||||||||||||
Synonyms | IMP-2; IMP2; VICKZ2; | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Protein | ENSP00000371634 | ||||||||||||||||||
InnateDB Gene | IDBG-68594 (IGF2BP2) | ||||||||||||||||||
Protein Structure | |||||||||||||||||||
UniProt Annotation | |||||||||||||||||||
Function | RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. Binds to beta- actin/ACTB and MYC transcripts. {ECO:0000250, ECO:0000269PubMed:23640942, ECO:0000269PubMed:9891060}. | ||||||||||||||||||
Subcellular Localization | Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Localizes at the connecting piece and the tail of the spermatozoa. In response to cellular stress, such as oxidative stress, recruited to stress granules. | ||||||||||||||||||
Disease Associations | |||||||||||||||||||
Tissue Specificity | Expressed in oocytes, granulosa cells of small and growing follicles, Leydig cells, spermatogonia and semen (at protein level). Expressed in testicular cancer (at protein level). Expressed weakly in heart, placenta, skeletal muscle, bone marrow, colon, kidney, salivary glands, testis and pancreas. Detected in fetal liver, fetal ovary, gonocytes and interstitial cells of the testis. {ECO:0000269PubMed:10190901, ECO:0000269PubMed:16049158}. | ||||||||||||||||||
Comments | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||
PDB ID | |||||||||||||||||||
InterPro |
IPR000504
RNA recognition motif domain IPR004087 K Homology domain IPR004088 K Homology domain, type 1 |
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PFAM |
PF00076
PF00013 PF13014 |
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PRINTS | |||||||||||||||||||
PIRSF | |||||||||||||||||||
SMART |
SM00360
SM00322 |
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TIGRFAMs | |||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||
Modification | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | Q9Y6M1 | ||||||||||||||||||
PhosphoSite | PhosphoSite-Q9Y6M1 | ||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 10644 | ||||||||||||||||||
UniGene | Hs.35354 | ||||||||||||||||||
RefSeq | NP_006539 | ||||||||||||||||||
HUGO | HGNC:28867 | ||||||||||||||||||
OMIM | 608289 | ||||||||||||||||||
CCDS | CCDS3273 | ||||||||||||||||||
HPRD | 10507 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AC016961 AC108670 AF057352 BC021290 EU408701 EU408702 EU408703 | ||||||||||||||||||
GenPept | AAD31596 AAH21290 ACB86625 ACB86626 ACB86627 | ||||||||||||||||||