Version 5.4
Homo sapiens Gene: IGF2BP2
Summary
InnateDB Gene IDBG-68594.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IGF2BP2
Gene Name insulin-like growth factor 2 mRNA binding protein 2
Synonyms IMP-2; IMP2; VICKZ2
Species Homo sapiens
Ensembl Gene ENSG00000073792
Encoded Proteins
IDBP-68596
insulin-like growth factor 2 mRNA binding protein 2
IDBP-68600
insulin-like growth factor 2 mRNA binding protein 2
IDBP-386299
insulin-like growth factor 2 mRNA binding protein 2
IDBP-386300
insulin-like growth factor 2 mRNA binding protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains several four KH domains and two RRM domains. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains four KH domains and two RRM domains. It functions by binding to the 5\' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation. Alternative promoter usage and alternate splicing result in multiple variants encoding different isoforms. [provided by RefSeq, May 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:185643739-185825056
Strand Reverse strand
Band q27.2
Transcripts
ENST00000382199 ENSP00000371634
ENST00000346192 ENSP00000320204
ENST00000421047 ENSP00000413787
ENST00000457616 ENSP00000410242
ENST00000464166
ENST00000494906
ENST00000496495
ENST00000461957
ENST00000493302
ENST00000466476
ENST00000466214
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
Experimentally validated
Total 35 [view]
Protein-Protein 33 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0003730 mRNA 3'-UTR binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
GO:0045182 translation regulator activity
GO:0048027 mRNA 5'-UTR binding
Biological Process
GO:0009653 anatomical structure morphogenesis
GO:0010467 gene expression
GO:0017148 negative regulation of translation
GO:0042035 regulation of cytokine biosynthetic process
GO:0051028 mRNA transport
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000033581
View Gene Order
ENSBTAG00000007666
Not yet available
Pathways
NETPATH
REACTOME
REACT_22166
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.35354
RefSeq NM_001007225 NM_001291869 NM_001291872 NM_001291873 NM_001291874 NM_001291875 NM_006548 XM_006713477
HUGO
OMIM
CCDS CCDS3273 CCDS33903
HPRD 10507
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca