InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IGF2BP2

Summary

InnateDB Protein

IDBP-68600.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IGF2BP2

Protein Name

insulin-like growth factor 2 mRNA binding protein 2

Synonyms

IMP-2; IMP2; VICKZ2;

Species

Homo sapiens

Ensembl Protein

ENSP00000320204

InnateDB Gene

IDBG-68594 (IGF2BP2)

Protein Structure

UniProt Annotation

Function

RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. Binds to beta- actin/ACTB and MYC transcripts. {ECO:0000250, ECO:0000269PubMed:23640942, ECO:0000269PubMed:9891060}.

Subcellular Localization

Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Localizes at the connecting piece and the tail of the spermatozoa. In response to cellular stress, such as oxidative stress, recruited to stress granules.

Disease Associations

Tissue Specificity

Expressed in oocytes, granulosa cells of small and growing follicles, Leydig cells, spermatogonia and semen (at protein level). Expressed in testicular cancer (at protein level). Expressed weakly in heart, placenta, skeletal muscle, bone marrow, colon, kidney, salivary glands, testis and pancreas. Detected in fetal liver, fetal ovary, gonocytes and interstitial cells of the testis. {ECO:0000269PubMed:10190901, ECO:0000269PubMed:16049158}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.

Experimentally validated
Total	35 [view]
Protein-Protein	33 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0003730	mRNA 3'-UTR binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding
GO:0045182	translation regulator activity
GO:0048027	mRNA 5'-UTR binding

Biological Process

GO:0009653	anatomical structure morphogenesis
GO:0010467	gene expression
GO:0017148	negative regulation of translation
GO:0042035	regulation of cytokine biosynthetic process
GO:0051028	mRNA transport