Version 5.4
Bos taurus Protein: CDH3
Summary
InnateDB Protein IDBP-686022.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDH3
Protein Name Cadherin-3
Synonyms CDH15;
Species Bos taurus
Ensembl Protein ENSBTAP00000042970
InnateDB Gene IDBG-634205 (CDH3)
Protein Structure
UniProt Annotation
Function Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
Subcellular Localization Cell membrane; Single-pass type I membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0046872 metal ion binding
Biological Process
GO:0001895 retina homeostasis
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion
GO:0010628 positive regulation of gene expression
GO:0010838 positive regulation of keratinocyte proliferation
GO:0016337 single organismal cell-cell adhesion
GO:0022405 hair cycle process
GO:0031424 keratinization
GO:0032773 positive regulation of monophenol monooxygenase activity
GO:0032912 negative regulation of transforming growth factor beta2 production
GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway
GO:0048023 positive regulation of melanin biosynthetic process
GO:0051796 negative regulation of catagen
GO:0060070 canonical Wnt signaling pathway
GO:0060901 regulation of hair cycle by canonical Wnt signaling pathway
GO:1902910 positive regulation of melanosome transport
Cellular Component
GO:0005886 plasma membrane
GO:0005913 cell-cell adherens junction
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000233 Cadherin, cytoplasmic domain
IPR002126 Cadherin
IPR014868 Cadherin prodomain
IPR015919 Cadherin-like
PFAM PF01049
PF00028
PF08758
PRINTS PR00205
PIRSF
SMART SM00112
SM01055
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P19535
PhosphoSite PhosphoSite-
TrEMBL E1BGT1
UniProt Splice Variant
Entrez Gene 281063
UniGene Bt.3948
RefSeq NP_001231534
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02046696 X53614
GenPept CAA37676

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca