Version 5.4
Bos taurus Protein: INHBA
Summary
InnateDB Protein IDBP-686292.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol INHBA
Protein Name Inhibin beta A chain
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000003783
InnateDB Gene IDBG-634513 (INHBA)
Protein Structure
UniProt Annotation
Function Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005125 cytokine activity
GO:0005179 hormone activity
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0017046 peptide hormone binding
GO:0042802 identical protein binding
GO:0070699 type II activin receptor binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0001541 ovarian follicle development
GO:0001707 mesoderm formation
GO:0001942 hair follicle development
GO:0002244 hematopoietic progenitor cell differentiation
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007050 cell cycle arrest
GO:0008285 negative regulation of cell proliferation
GO:0008584 male gonad development
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0030308 negative regulation of cell growth
GO:0032270 positive regulation of cellular protein metabolic process
GO:0032924 activin receptor signaling pathway
GO:0035987 endodermal cell differentiation
GO:0040007 growth
GO:0042476 odontogenesis
GO:0042493 response to drug
GO:0042541 hemoglobin biosynthetic process
GO:0042701 progesterone secretion
GO:0045648 positive regulation of erythrocyte differentiation
GO:0045786 negative regulation of cell cycle
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046880 regulation of follicle-stimulating hormone secretion
GO:0048333 mesodermal cell differentiation
GO:0060021 palate development
GO:0060279 positive regulation of ovulation
GO:0061029 eyelid development in camera-type eye
GO:0097191 extrinsic apoptotic signaling pathway
GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0005576 extracellular region
GO:0043509 activin A complex
GO:0043512 inhibin A complex
Protein Structure and Domains
PDB ID
InterPro IPR000491 Inhibin, beta A subunit
IPR001111 Transforming growth factor-beta, N-terminal
IPR001839 Transforming growth factor-beta, C-terminal
IPR002405 Inhibin, alpha subunit
IPR029034 Cystine-knot cytokine
PFAM PF00688
PF00019
PRINTS PR00670
PR00669
PIRSF
SMART SM00204
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P07995
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 281867
UniGene Bt.12760
RefSeq NP_776788
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC126556 M13274 U16238 U16239
GenPept AAA97415 AAB60627 AAI26557

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca