InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: ACADVL

Summary

InnateDB Protein

IDBP-686361.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACADVL

Protein Name

Very long-chain specific acyl-CoA dehydrogenase, mitochondrial

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000003999

InnateDB Gene

IDBG-634579 (ACADVL)

Protein Structure

UniProt Annotation

Function

Active toward esters of long-chain and very long chain fatty acids such as palmitoyl-CoA, myristoyl-CoA and stearoyl-CoA. Can accommodate substrate acyl chain lengths as long as 24 carbons, but shows little activity for substrates of less than 12 carbons.

Subcellular Localization

Mitochondrion inner membrane.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003995	acyl-CoA dehydrogenase activity
GO:0016491	oxidoreductase activity
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors
GO:0050660	flavin adenine dinucleotide binding

Biological Process

GO:0001659	temperature homeostasis
GO:0006629	lipid metabolic process
GO:0006631	fatty acid metabolic process
GO:0008152	metabolic process
GO:0030855	epithelial cell differentiation
GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GO:0045717	negative regulation of fatty acid biosynthetic process
GO:0046322	negative regulation of fatty acid oxidation
GO:0055114	oxidation-reduction process
GO:0090181	regulation of cholesterol metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0016020	membrane
GO:0042645	mitochondrial nucleoid

Protein Structure and Domains

PDB ID

InterPro

IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain
IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal
IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain
IPR013107 Acyl-CoA dehydrogenase, C-terminal domain
IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal

PFAM

PF02770
PF00441
PF08028
PF02771

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P48818

PhosphoSite