Version 5.4
Bos taurus Protein: IL1RN
Summary
InnateDB Protein IDBP-686453.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL1RN
Protein Name Interleukin-1 receptor antagonist protein
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000026209
InnateDB Gene IDBG-634670 (IL1RN)
Protein Structure
UniProt Annotation
Function Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005149 interleukin-1 receptor binding
GO:0005150 interleukin-1, Type I receptor binding
GO:0005151 interleukin-1, Type II receptor binding
GO:0005152 interleukin-1 receptor antagonist activity
GO:0045352 interleukin-1 Type I receptor antagonist activity
GO:0045353 interleukin-1 Type II receptor antagonist activity
Biological Process
GO:0001960 negative regulation of cytokine-mediated signaling pathway
GO:0006629 lipid metabolic process
GO:0006953 acute-phase response
GO:0030073 insulin secretion
GO:0034115 negative regulation of heterotypic cell-cell adhesion
GO:0051384 response to glucocorticoid
GO:2000660 negative regulation of interleukin-1-mediated signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0031982 vesicle
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000975 Interleukin-1 family
IPR003297 Interleukin-1 receptor antagonist / Interleukin-36
IPR008996 Cytokine, IL-1-like
PFAM PF00340
PRINTS PR00264
PR01360
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O77482
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 281860
UniGene
RefSeq NP_776782
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AB005148
GenPept BAA31854

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca