InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: IL1RN

Summary

InnateDB Gene

IDBG-634670.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL1RN

Gene Name

Interleukin-1 receptor antagonist protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000019665

Encoded Proteins

IDBP-686453

Interleukin-1 receptor antagonist protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136689:
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:46699166-46706152

Strand

Forward strand

Band

Transcripts

ENSBTAT00000026209

ENSBTAP00000026209

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005149	interleukin-1 receptor binding
GO:0005150	interleukin-1, Type I receptor binding
GO:0005151	interleukin-1, Type II receptor binding
GO:0005152	interleukin-1 receptor antagonist activity
GO:0045352	interleukin-1 Type I receptor antagonist activity
GO:0045353	interleukin-1 Type II receptor antagonist activity

Biological Process

GO:0001960	negative regulation of cytokine-mediated signaling pathway
GO:0006629	lipid metabolic process
GO:0006953	acute-phase response
GO:0030073	insulin secretion
GO:0034115	negative regulation of heterotypic cell-cell adhesion
GO:0051384	response to glucocorticoid
GO:2000660	negative regulation of interleukin-1-mediated signaling pathway