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InnateDB Protein
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IDBP-686469.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SIKE1
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Protein Name
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Suppressor of IKBKE 1
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Synonyms
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SIKE;
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000021254
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InnateDB Gene
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IDBG-634688 (SIKE1)
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Protein Structure
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| Function |
Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways (By similarity). {ECO:0000250}.
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| Subcellular Localization |
Cytoplasm {ECO:0000250}.
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| Disease Associations |
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| Tissue Specificity |
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
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| Predicted by orthology |
| Total |
26 [view]
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Molecular Function |
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| Biological Process |
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| Cellular Component |
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| PDB ID |
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| InterPro |
IPR008555
Suppressor of IKBKE 1
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| PFAM |
PF05769
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| PRINTS |
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| PIRSF |
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
Q0VCF3
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| PhosphoSite |
PhosphoSite-
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| TrEMBL |
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| UniProt Splice Variant |
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| Entrez Gene |
506848
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| UniGene |
Bt.20253
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| RefSeq |
NP_001068749
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| HUGO |
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| OMIM |
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| CCDS |
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| HPRD |
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| IMGT |
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| EMBL |
BC120197
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| GenPept |
AAI20198
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Version 5.4