InnateDB Protein
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IDBP-68662.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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GYPC
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Protein Name
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glycophorin C (Gerbich blood group)
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Synonyms
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CD236; CD236R; GE; GPC; GPD; GYPD; PAS-2; PAS-2\';
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000349354
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InnateDB Gene
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IDBG-68658 (GYPC)
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Protein Structure
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Function |
This protein is a minor sialoglycoprotein in human erythrocyte membranes. The blood group Gerbich antigens and receptors for Plasmodium falciparum merozoites are most likely located within the extracellular domain. Glycophorin-C plays an important role in regulating the stability of red cells.
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Subcellular Localization |
Cell membrane; Single-pass type III membrane protein. Note=Linked to the membrane via band 4.1.
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Disease Associations |
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Tissue Specificity |
Glycophorin-C is expressed in erythrocytes. Glycophorin-D and IsoGPC are ubiquitously expressed. {ECO:0000269PubMed:2349119}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
5
[view]
|
Protein-Protein |
4
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR003585
Neurexin/syndecan/glycophorin C
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
SM00294
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TIGRFAMs |
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Modification |
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SwissProt |
P04921
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PhosphoSite |
PhosphoSite-P04921
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TrEMBL |
A8D444
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UniProt Splice Variant |
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Entrez Gene |
2995
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UniGene |
Hs.59138
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RefSeq |
NP_001243513
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HUGO |
HGNC:4704
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OMIM |
110750
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CCDS |
CCDS58724
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HPRD |
00193
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IMGT |
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EMBL |
AC013474
AK312032
AY838876
BC104246
BC104247
BC106051
EU137141
EU137142
EU137143
M11802
M28335
M29662
M36284
X12496
X13890
X13892
X13893
X14242
X51973
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GenPept |
AAA52574
AAA52625
AAA52626
AAA60023
AAI04247
AAI04248
AAI06052
AAV80423
AAY14660
ABV55110
ABV55111
ABV55112
BAG34969
CAA31016
CAA32093
CAA32458
CAA36235
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