Homo sapiens Gene: GYPC
Summary
InnateDB Gene IDBG-68658.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GYPC
Gene Name glycophorin C (Gerbich blood group)
Synonyms CD236; CD236R; GE; GPC; GPD; GYPD; PAS-2; PAS-2\';
Species Homo sapiens
Ensembl Gene ENSG00000136732
Encoded Proteins
glycophorin C (Gerbich blood group)
glycophorin C (Gerbich blood group)
glycophorin C (Gerbich blood group)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Glycophorin C (GYPC) is an integral membrane glycoprotein. It is a minor species carried by human erythrocytes, but plays an important role in regulating the mechanical stability of red cells. A number of glycophorin C mutations have been described. The Gerbich and Yus phenotypes are due to deletion of exon 3 and 2, respectively. The Webb and Duch antigens, also known as glycophorin D, result from single point mutations of the glycophorin C gene. The glycophorin C protein has very little homology with glycophorins A and B. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:126655933-126696675
Strand Forward strand
Band q14.3
Transcripts
ENST00000259254 ENSP00000259254
ENST00000356887 ENSP00000349354
ENST00000409836 ENSP00000386904
ENST00000484700
ENST00000459787
ENST00000464053
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0030863 cortical cytoskeleton
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
KEGG
Malaria pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.59138
RefSeq NM_001256584 NM_002101 NM_016815 XM_006712460
HUGO
OMIM
CCDS CCDS2136 CCDS46402 CCDS58724
HPRD 00193
IMGT
EMBL
GenPept
RNA Seq Atlas