Version 5.4
Bos taurus Protein: CAPG
Summary
InnateDB Protein IDBP-687007.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CAPG
Protein Name Macrophage-capping protein
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000007150
InnateDB Gene IDBG-635176 (CAPG)
Protein Structure
UniProt Annotation
Function Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Secreted {ECO:0000250}. Melanosome {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
Biological Process
GO:0030031 cell projection assembly
GO:0051693 actin filament capping
Cellular Component
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0031965 nuclear membrane
GO:0042470 melanosome
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR007122 Villin/Gelsolin
IPR007123 Gelsolin-like domain
PFAM PF00626
PRINTS PR00597
PIRSF
SMART SM00262
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q865V6
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 353121
UniGene Bt.5499
RefSeq NP_848669
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AY219899 BC102160
GenPept AAI02161 AAO38847

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca