Version 5.4
Bos taurus Protein: SHMT2
Summary
InnateDB Protein IDBP-687155.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SHMT2
Protein Name Serine hydroxymethyltransferase, mitochondrial
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000038059
InnateDB Gene IDBG-635321 (SHMT2)
Protein Structure
UniProt Annotation
Function Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA (By similarity). {ECO:0000250}.
Subcellular Localization Mitochondrion {ECO:0000250}. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000250}. Mitochondrion inner membrane {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Predicted by orthology
Total 22 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0003824 catalytic activity
GO:0004372 glycine hydroxymethyltransferase activity
GO:0016740 transferase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0006544 glycine metabolic process
GO:0006563 L-serine metabolic process
GO:0006730 one-carbon metabolic process
GO:0035999 tetrahydrofolate interconversion
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
GO:0015630 microtubule cytoskeleton
GO:0016020 membrane
GO:0042645 mitochondrial nucleoid
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001085 Serine hydroxymethyltransferase
IPR015424 Pyridoxal phosphate-dependent transferase
PFAM PF00464
PRINTS
PIRSF PIRSF000412
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3SZ20
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 507197
UniGene Bt.49106
RefSeq NP_001029454
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC103242
GenPept AAI03243

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca