Version 5.4
Bos taurus Protein: SERPINH1
Summary
InnateDB Protein IDBP-687468.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SERPINH1
Protein Name Serpin H1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000039506
InnateDB Gene IDBG-635624 (SERPINH1)
Protein Structure
UniProt Annotation
Function Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen (By similarity). {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum lumen {ECO:0000255PROSITE-ProRule:PRU10138}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 59 interaction(s) predicted by orthology.
Predicted by orthology
Total 59 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
GO:0051082 unfolded protein binding
Biological Process
GO:0003433 chondrocyte development involved in endochondral bone morphogenesis
GO:0010951 negative regulation of endopeptidase activity
GO:0030162 regulation of proteolysis
GO:0030199 collagen fibril organization
GO:0032964 collagen biosynthetic process
GO:0051604 protein maturation
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR023796 Serpin domain
PFAM PF00079
PRINTS
PIRSF
SMART SM00093
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q2KJH6
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 510850
UniGene Bt.21385
RefSeq NP_001039528
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC105338
GenPept AAI05339

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca