InnateDB Protein
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IDBP-68755.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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HIST1H1D
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Protein Name
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histone cluster 1, H1d
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Synonyms
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H1.3; H1D; H1F3; H1s-2;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000244534
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InnateDB Gene
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IDBG-68753 (HIST1H1D)
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Protein Structure
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Function |
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus. Chromosome. Note=According to PubMed:15911621 more commonly found in euchromatin. According to PubMed:10997781 is associated with inactive chromatin.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
33
[view]
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Protein-Protein |
33
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR005818
Linker histone H1/H5, domain H15
IPR005819
Histone H5
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PFAM |
PF00538
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PRINTS |
PR00624
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PIRSF |
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SMART |
SM00526
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TIGRFAMs |
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Modification |
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SwissProt |
P16402
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PhosphoSite |
PhosphoSite-P16402
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
3007
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UniGene |
Hs.136857
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RefSeq |
NP_005311
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HUGO |
HGNC:4717
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OMIM |
142210
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CCDS |
CCDS4597
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HPRD |
06764
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IMGT |
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EMBL |
AF531303
AK312845
AL031777
BC104874
BC111971
CH471087
M60747
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GenPept |
AAA63186
AAI04875
AAI11972
AAN06703
BAG35698
CAB39189
EAW55548
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