Version 5.4
Bos taurus Protein: MIP
Summary
InnateDB Protein IDBP-687795.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MIP
Protein Name Lens fiber major intrinsic protein
Synonyms AQP0; MP22; MP26;
Species Bos taurus
Ensembl Protein ENSBTAP00000013360
InnateDB Gene IDBG-635918 (MIP)
Protein Structure
UniProt Annotation
Function Water channel. Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core. {ECO:0000269PubMed:23893133}.
Subcellular Localization Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
Disease Associations
Tissue Specificity Major component of lens fiber gap junctions.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005212 structural constituent of eye lens
GO:0005215 transporter activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0015250 water channel activity
Biological Process
GO:0002088 lens development in camera-type eye
GO:0006810 transport
GO:0006833 water transport
GO:0007601 visual perception
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005921 gap junction
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
Protein Structure and Domains
PDB ID
InterPro IPR000425 Major intrinsic protein
IPR023271 Aquaporin-like
PFAM PF00230
PRINTS PR00783
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P06624
PhosphoSite PhosphoSite-P06624
TrEMBL
UniProt Splice Variant
Entrez Gene 280859
UniGene Bt.4516
RefSeq NP_776362
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL K02818
GenPept AAA30622

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca