Version 5.4
Bos taurus Protein: MEFV
Summary
InnateDB Protein IDBP-687815.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MEFV
Protein Name Mediterranean fever
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000025458
InnateDB Gene IDBG-635925 (MEFV)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0008270 zinc ion binding
Biological Process
GO:0006954 inflammatory response
GO:0032691 negative regulation of interleukin-1 beta production
GO:0032695 negative regulation of interleukin-12 production
GO:0050728 negative regulation of inflammatory response
GO:0071641 negative regulation of macrophage inflammatory protein 1 alpha production
GO:2001056 positive regulation of cysteine-type endopeptidase activity
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005875 microtubule associated complex
Protein Structure and Domains
PDB ID
InterPro IPR000315 Zinc finger, B-box
IPR004020 DAPIN domain
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR011029 Death-like domain
PFAM PF00643
PF02758
PRINTS
PIRSF
SMART SM00336
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E1B7P5
UniProt Splice Variant
Entrez Gene 101902981
UniGene Bt.18827
RefSeq XP_005224734
HUGO HGNC:6998
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02057327
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca