InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TACC3

Summary

InnateDB Protein

IDBP-6879.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TACC3

Protein Name

transforming, acidic coiled-coil containing protein 3

Synonyms

ERIC-1; ERIC1;

Species

Homo sapiens

Ensembl Protein

ENSP00000326550

InnateDB Gene

IDBG-6877 (TACC3)

Protein Structure

UniProt Annotation

Function

Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May be involved in the control of cell growth and differentiation. May contribute to cancer. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.

Experimentally validated
Total	34 [view]
Protein-Protein	34 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019904	protein domain specific binding

Biological Process

GO:0000226	microtubule cytoskeleton organization
GO:0001666	response to hypoxia
GO:0008283	cell proliferation
GO:0021987	cerebral cortex development
GO:0022008	neurogenesis
GO:0022027	interkinetic nuclear migration
GO:0030097	hemopoiesis
GO:0030953	astral microtubule organization
GO:0032886	regulation of microtubule-based process
GO:0042994	cytoplasmic sequestering of transcription factor
GO:0051726	regulation of cell cycle