Version 5.4
Homo sapiens Gene: TACC3
Summary
InnateDB Gene IDBG-6877.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TACC3
Gene Name transforming, acidic coiled-coil containing protein 3
Synonyms ERIC-1; ERIC1
Species Homo sapiens
Ensembl Gene ENSG00000013810
Encoded Proteins
IDBP-6879
transforming, acidic coiled-coil containing protein 3
IDBP-360803
transforming, acidic coiled-coil containing protein 3
IDBP-473654
transforming, acidic coiled-coil containing protein 3
IDBP-479368
transforming, acidic coiled-coil containing protein 3
IDBP-478340
transforming, acidic coiled-coil containing protein 3
IDBP-485237
transforming, acidic coiled-coil containing protein 3
IDBP-811226
transforming, acidic coiled-coil containing protein 3
IDBP-811227
transforming, acidic coiled-coil containing protein 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the transforming acidic colied-coil protein family. The encoded protein is a motor spindle protein that may play a role in stabilization of the mitotic spindle. This protein may also play a role in growth a differentiation of certain cancer cells. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:1721490-1745176
Strand Forward strand
Band p16.3
Transcripts
ENST00000313288 ENSP00000326550
ENST00000458173 ENSP00000415914
ENST00000485989 ENSP00000419210
ENST00000484651
ENST00000467746 ENSP00000418727
ENST00000493975 ENSP00000418095
ENST00000470136 ENSP00000420838
ENST00000466077
ENST00000470808
ENST00000484264
ENST00000617535 ENSP00000483196
ENST00000612220 ENSP00000478580
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
Experimentally validated
Total 34 [view]
Protein-Protein 34 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019904 protein domain specific binding
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0001666 response to hypoxia
GO:0008283 cell proliferation
GO:0021987 cerebral cortex development
GO:0022008 neurogenesis
GO:0022027 interkinetic nuclear migration
GO:0030097 hemopoiesis
GO:0030953 astral microtubule organization
GO:0032886 regulation of microtubule-based process
GO:0042994 cytoplasmic sequestering of transcription factor
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005737 cytoplasm
GO:0005813 centrosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000037313
View Gene Order
ENSBTAG00000011044
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa03013
RNA transport pathway
INOH
PID NCI
aurora_a_pathway
Aurora A signaling
ilk_pathway
Integrin-linked kinase signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.104019
RefSeq NM_006342 XM_005247929 XM_005247930
HUGO
OMIM
CCDS CCDS3352
HPRD 05601
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca