Version 5.4
Bos taurus Protein: BDNF
Summary
InnateDB Protein IDBP-687996.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BDNF
Protein Name Brain-derived neurotrophic factor
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000010694
InnateDB Gene IDBG-636102 (BDNF)
Protein Structure
UniProt Annotation
Function During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS (By similarity). {ECO:0000250}.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
Biological Process
GO:0001657 ureteric bud development
GO:0001662 behavioral fear response
GO:0007214 gamma-aminobutyric acid signaling pathway
GO:0007406 negative regulation of neuroblast proliferation
GO:0007411 axon guidance
GO:0007412 axon target recognition
GO:0007611 learning or memory
GO:0007623 circadian rhythm
GO:0007631 feeding behavior
GO:0008038 neuron recognition
GO:0014047 glutamate secretion
GO:0016358 dendrite development
GO:0019222 regulation of metabolic process
GO:0021675 nerve development
GO:0032229 negative regulation of synaptic transmission, GABAergic
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0042490 mechanoreceptor differentiation
GO:0042493 response to drug
GO:0042596 fear response
GO:0043066 negative regulation of apoptotic process
GO:0043523 regulation of neuron apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0045666 positive regulation of neuron differentiation
GO:0046668 regulation of retinal cell programmed cell death
GO:0048167 regulation of synaptic plasticity
GO:0048675 axon extension
GO:0048839 inner ear development
GO:0051965 positive regulation of synapse assembly
GO:0060548 negative regulation of cell death
GO:0061193 taste bud development
GO:0097484 dendrite extension
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR002072 Nerve growth factor-related
IPR020408 Nerve growth factor-like
IPR020430 Brain-derived neurotrophic factor
IPR029034 Cystine-knot cytokine
PFAM PF00243
PRINTS PR00268
PR01912
PIRSF PIRSF001789
SMART SM00140
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q95106
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 617701
UniGene Bt.36284
RefSeq NP_001040072
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC109860 X97914
GenPept AAI09861 CAA66488

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca