InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: RTCA

Summary

InnateDB Protein

IDBP-688094.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RTCA

Protein Name

RNA 3'-terminal phosphate cyclase

Synonyms

RTCD1;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000008293

InnateDB Gene

IDBG-636183 (RTCA)

Protein Structure

UniProt Annotation

Function

Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA- N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'- phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus, nucleoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003824	catalytic activity
GO:0003963	RNA-3'-phosphate cyclase activity
GO:0005524	ATP binding
GO:0016874	ligase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006396

RNA processing

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000228 RNA 3\'-terminal phosphate cyclase
IPR013791 RNA 3\'-terminal phosphate cyclase, insert domain
IPR013792 RNA 3\'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta
IPR017770 RNA 3\'-terminal phosphate cyclase type 1
IPR023797 RNA 3\'-terminal phosphate cyclase domain

PFAM

PF05189
PF01137

PRINTS

PIRSF

PIRSF005378

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q2HJ88