InnateDB Protein
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IDBP-688408.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CD63
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Protein Name
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CD63 antigen
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Synonyms
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000015829
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InnateDB Gene
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IDBG-636480 (CD63)
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Protein Structure
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Function |
Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Lysosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Late endosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endosome, multivesicular body {ECO:0000250}. Melanosome {ECO:0000250}. Note=Also found in Weibel-Palade bodies of endothelial cells. Located in platelet dense granules. Detected in a subset of pre-melanosomes. Detected on intralumenal vesicles (ILVs) within multivesicular bodies (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
14 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000301
Tetraspanin
IPR008952
Tetraspanin, EC2 domain
IPR018499
Tetraspanin/Peripherin
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PFAM |
PF00335
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PRINTS |
PR00259
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PIRSF |
PIRSF002419
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9XSK2
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PhosphoSite |
PhosphoSite-
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TrEMBL |
B0JYM4
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UniProt Splice Variant |
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Entrez Gene |
404156
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UniGene |
Bt.13496
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RefSeq |
NP_991372
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HUGO |
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AJ012589
BC102657
BC151412
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GenPept |
AAI02658
AAI51413
CAB40564
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