InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CD63

Summary

InnateDB Gene

IDBG-636480.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD63

Gene Name

CD63 antigen

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000011931

Encoded Proteins

IDBP-688408

CD63 antigen

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 18930046

[Homo sapiens] Forms a complex with ELANE (neutrophil elastase 2) and plays a role in the targeting of ELANE to primary granules in neutrophils

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135404:
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Apr 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:57854278-57857485

Strand

Forward strand

Band

Transcripts

ENSBTAT00000015829

ENSBTAP00000015829

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0002092	positive regulation of receptor internalization
GO:0006810	transport
GO:0007160	cell-matrix adhesion
GO:0015031	protein transport
GO:0016477	cell migration
GO:0035646	endosome to melanosome transport
GO:0048757	pigment granule maturation
GO:1900746	regulation of vascular endothelial growth factor signaling pathway
GO:2001046	positive regulation of integrin-mediated signaling pathway

Cellular Component

GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0005768	endosome
GO:0005771	multivesicular body
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031226	intrinsic component of plasma membrane
GO:0031902	late endosome membrane
GO:0042470	melanosome
GO:0097487	multivesicular body, internal vesicle